Alpha Omega was founded in 1976 by a group of friends and businessmen in Boston, Massachusetts, under the leadership of the late Peter Agris, the publisher of The Hellenic Chronicle, an English-language weekly newspaper targeting the Greek-American community.

The Alpha Omega Council is comprised of Americans of Hellenic ancestry in Business, Education, Academia,Medicine, Law, Politics, Science and other fields. Its mission is to promote and encourage loyalty and patriotism to the United States of America; to cultivate the ideals of Hellenism; to constantly strive towards maintaining positive Greek-American relations; to unite Americans of Greek descent in fellowship and philanthropy; to help recognize the achievements of those who excel in their field individually or as a group; to help alleviate the wants of the poor and needy; and to establish, maintain or aid religious, charitable, scientific, literary or educational activities. Since its inception, the Alpha Omega Council has contributed over $2,000,000 to various philanthropic causes, not including the annual Peter Agris Memorial Journalism Scholarship Awards.